Endothelio- and cardioprotective effects of vitamin в6 and folic acid in modelling methionine-induced hyperhomocysteinemia

Authors

  • Vladimir Ya. Provotorov Kursk State Medical University
  • Mikhail Viktorovich Korokin Belgorod National Research University ORCID logo https://orcid.org/0000-0001-5402-0697
  • Mikhail Vladimirovich Pokrovskii Belgorod National Research University ORCID logo https://orcid.org/0000-0002-1493-3376
  • Sergej V. Povetkin State Medical University
  • Galina A. Lazareva Kursk State Medical University
  • Aleksandr A. Stepchenko
  • Natalya A. Bystrova Kursk State Medical University

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-16-19

Abstract

The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows on the background of a significant reduction in homocysteine concentrations normalizing the endothelial dysfunction coefficient and the parameters of maximum left ventricular pressure in response to intravenous administration of adrenaline. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.

Keywords:

endothelial dysfunction, folic acid, vitamin B6, hyperhomocysteinemia

Author Contribution

Vladimir Ya. Provotorov, Kursk State Medical University

Doctor of Medical Sciences, Professor of the Department of infectious diseases of Kursk State Medical University, Kursk, Russia

Mikhail Viktorovich Korokin, Belgorod National Research University

Doctor of medicine, professor of the pharmacological department of Medical Institute of Belgorod State National Research University, Belgorod, Russia

 

Mikhail Vladimirovich Pokrovskii, Belgorod National Research University

PhD, MD, Prof.; Head of the Department of Pharmacology of Belgorod State National Research University, Belgorod, Russia 

Sergej V. Povetkin, State Medical University

Doctor of Medical Sciences, Professor; Department of Clinical Pharmacology and Pharmacotherapy Kursk State Medical University, Kursk, Russia 

Galina A. Lazareva, Kursk State Medical University

Doctor of Medical Sciences, Professor of the Department of obstetrics and gynecology of Kursk State Medical University, Kursk, Russia 

Aleksandr A. Stepchenko

Doctor of Medical Sciences, Kursk State Medical University, Russia

Natalya A. Bystrova, Kursk State Medical University

Doctor of Medical Sciences, Professor, Kursk State Medical University

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Published

31-03-2016

How to Cite

Provotorov VY, Korokin MV, Pokrovskii MV, Povetkin SV, Lazareva GA, Stepchenko AA, Bystrova NA (2016) Endothelio- and cardioprotective effects of vitamin в6 and folic acid in modelling methionine-induced hyperhomocysteinemia. Research Results in Pharmacology 2(1): 16–19. https://doi.org/10.18413/2313-8971-2016-2-1-16-19

Issue

Vol. 2 No. 1 (2016)

Section

Review article

License

Copyright (c) 2016 Research Results in Pharmacology

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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