Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties

Authors

Abstract

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practice.

Keywords:

compound SS-68, HPLC-MS/MS, pharmacokinetic studies, plasma of rabbits

Author Contribution

Pavel Alexandrovich Galenko-Yaroshevsky, Kuban State Medical University

Corresponding member of RAMS, Doctor of Medicine, Professor, Head of the Department of Pharmacology of Kuban State Medical University, Krasnodar, Russia

Alexandr Kulikov, Belgorod National Research University

Graduate student of the Department of pharmacology of Medical University of NRU BelSU, Belgorod, Russia 

Dmitry V. Vinakov, Belgorod National Research University

Graduate student of the Department of pharmacology of Medical University of NRU BelSU,
Belgorod, Russia

Tatyana Valeryevna Avtina, Belgorod National Research University

PhD in Pharmaceutical Sciences, Associate Professor, Department of Pharmacology of Medical University of NRU BelSU, Belgorod, Russia
Scopus

Konstantin Suzdalev, Southern Federal University

PhD in Chemical Sciences, associate Professor of the Department of chemistry of natural and macromolecular compounds, Southern Federal University, Rostov-on-don, Russia 

Mikhail Vladimirovich Pokrovskii, Belgorod National Research University

Doctor of Medical Sciences, Professor, Department of pharmacology of Medical University of NRU BelSU,
Belgorod, Russia

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Published

20-03-2016

How to Cite

Galenko-Yaroshevsky PA, Kulikov A, Vinakov DV, Avtina TV, Suzdalev K, Pokrovskii MV (2016) Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties. Research Results in Pharmacology: 20–24

Issue

Vol. 2 No. 2 (2016)

Section

Review article

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