Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection
DOI:
https://doi.org/10.18413/2313-8971-2016-2-1-52-57Abstract
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.
Keywords:
antidiabetic agent, С7070, the blood plasma of rats, high-performance liquid chromatography, mass spectrometric detection, validationDownloads
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Copyright (c) 2016 Research Results in Pharmacology
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