Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection
Авторы
- Andrey A. Buzov CJSC "VladMiVa"
- Alexandr Kulikov Belgorod National Research University
-
Tatyana Valeryevna Avtina
Belgorod National Research University
https://orcid.org/0000-0003-0509-5996
-
Mikhail Vladimirovich Pokrovskii
Belgorod National Research University
https://orcid.org/0000-0002-1493-3376
-
Ol'ga A. Osipova
Belgorod State National Research University
https://orcid.org/0000-0002-7321-6529
DOI:
https://doi.org/10.18413/2313-8971-2016-2-1-52-57Аннотация
We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.
Ключевые слова:
antidiabetic agent, С7070, the blood plasma of rats, high-performance liquid chromatography, mass spectrometric detection, validationЗагрузки
Опубликован
31.03.2016
Как цитировать
Buzov AA, Kulikov A, Avtina TV, Pokrovskii MV, Osipova OA (2016) Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection. Research Results in Pharmacology 2(1). https://doi.org/10.18413/2313-8971-2016-2-1-52-57
Выпуск
Раздел
Обзорная статья
Лицензия
Copyright (c) 2016 Research Results in Pharmacology
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Русский
English
