Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection

Authors

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-52-57

Abstract

We developed a method of quantification of the new antidiabetic drug 3-(1h-benzimidazole-2-yl)-1,2,2-trimethyl-cyclopentane-carbonic acid (c7070) in the blood plasma of rats by high-performance liquid chromatography with mass-spectrometric detection. The analytical range of the method was 0.02-3876.0 μg in 1 ml of blood plasma. The research was partially supported by the grant of the President of the Russian Federation № MD-4711.2015.7 and МК-6135.2016.4.

Keywords:

antidiabetic agent, С7070, the blood plasma of rats, high-performance liquid chromatography, mass spectrometric detection, validation

Author Contribution

Andrey A. Buzov, CJSC "VladMiVa"

CJSC "VladMiVa", Belgorod, Russia

Alexandr Kulikov, Belgorod National Research University

Graduate student of the Department of pharmacology of Medical University of NRU BelSU, Belgorod, Russia

Tatyana Valeryevna Avtina, Belgorod National Research University

PhD in Pharmaceutical Sciences, Associate Professor, Department of Pharmacology of Belgorod State National Research University, Belgorod, Russia
Scopus

Mikhail Vladimirovich Pokrovskii, Belgorod National Research University

Doctor of Medical Sciences, Professor; Department of pharmacology of Belgorod State National Research University, Belgorod, Russia

Ol'ga A. Osipova, Belgorod State National Research University

Doctor of medical sciences, Belgorod State National Research University, Belgorod, Russia 

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Published

31-03-2016

How to Cite

Buzov AA, Kulikov A, Avtina TV, Pokrovskii MV, Osipova OA (2016) Development and validation of methods of quantitative determination of the new antidiabetic drug in the blood plasma of rats by high performance liquid chromatography with mass spectrometric detection. Research Results in Pharmacology 2(1). https://doi.org/10.18413/2313-8971-2016-2-1-52-57

Issue

Vol. 2 No. 1 (2016)

Section

Review article

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Copyright (c) 2016 Research Results in Pharmacology

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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