Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heart

Authors

  • Oleg Georgievich Kesarev "Russian scientific center for security biologically active substances" (JSC "all-Russian scientific centre BAS")
  • Lyudmila Mikhailovna Danilenko Belgorod State University
  • Mikhail Vladimirovich Pokrovskii Belgorod State University
  • Alena Sergeevna Timokhina Belgorod State University
  • Anatolii Vyacheslavovich Khavanskii Belgorod State University

Abstract

In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high heart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate. The results indicate that Mexicor at the dose of 21.43 mg/kg/day does not provide a cardioprotective effect in this model of pathology. Mexicor has the cardioprotective effect at the dose of 85.72 mg/kg/day in relation to the isolated heart, that is resulted in the recovery of the contractile function of the heart and reducing the "diastole defect" (SТТI).

Keywords:

2-ethyl-6-methyl-3 hydroxypyridine succinate, doxorubicin, reperfusion, isolated heart, antioxidant

Author Contribution

Oleg Georgievich Kesarev, "Russian scientific center for security biologically active substances" (JSC "all-Russian scientific centre BAS")

PhD in Chemical Sciences, head the sector of technology of synthesis substances.

Lyudmila Mikhailovna Danilenko, Belgorod State University

PhD in pharmaceutical sciences, assistant professor of Department of Pharmacology of Medical institute.

Mikhail Vladimirovich Pokrovskii, Belgorod State University

Doctor of Medicine, Professor; Head of the Department of Pharmacology of Medical institute.

Alena Sergeevna Timokhina, Belgorod State University

Postgraduate student of the Department of Pharmacology of Medical institute.

Anatolii Vyacheslavovich Khavanskii, Belgorod State University

Master of Biological Science of the Department of Pharmacology of Medical institute.

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Published

30-03-2017

How to Cite

Kesarev OG, Danilenko LM, Pokrovskii MV, Timokhina AS, Khavanskii AV (2017) Study of dose-dependent effect of 2-ethyl-6-methyl-3 hydroxypyridine succinate on the contractile function of isolated rat heart. Research Results in Pharmacology 3(1): 3–9

Issue

Vol. 3 No. 1 (2017)

Section

Experimental Pharmacology

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