Test-system for estimation of activity of GSK-3 inhibitors as antihypoxants and differentiation of endothelial progenitors in vitro

Authors

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-58-62

Abstract

A model test-system was developed for validation in vitro of antihypoxic and endothelio-differentiating activity of newly created glycogen synthase kinase-3 inhibitors in comparison with the reference drug β4-thymosin.

Keywords:

glycogen synthase kinase-3, GSK-3; β4-thymosin, hypoxia, ischemia, endothelium

Author Contribution

Youri E. Burda, Belgorod National Research University

PhD, MD, Assoc. Prof., Department of Pharmacology of Belgorod State National Research University, Belgorod, Russia
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Sergey V. Nadezhdin, Belgorod National Research University

PhD, Assoc. Prof. Head of the Experimental-Industrial Department “Cellular and Assisted Reproductive Technologies” of Belgorod State National Research University, Belgorod, Russia

Ekaterina V. Zubareva, Belgorod National Research University

PhD, Scientific associate; Experimental-Industrial Department “Cellular and Assisted Reproductive Technologies” of Belgorod State National Research University, Belgorod, Russia

Mikhail Vladimirovich Pokrovskii, Belgorod National Research University

PhD, MD, Prof.; Head of the Department of Pharmacology of Belgorod State National Research University, Belgorod, Russia

Alexander V. Faitelson, Kursk State Medical University

Doctor of Medical Sciences, Associate Professor. Department of Traumatology and Orthopedics Kursk State Medical University, Kursk, Russia  

Svetlana Burda, Kursk State Medical University

Student of Kursk State Medical University, Kursk, Russia

Maria S. Shirina, Belgorod National Research University

Student of Belgorod State National Research University, Belgorod, Russia

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Published

31-03-2016

How to Cite

Burda YE, Nadezhdin SV, Zubareva EV, Pokrovskii MV, Faitelson AV, Burda S, Shirina MS (2016) Test-system for estimation of activity of GSK-3 inhibitors as antihypoxants and differentiation of endothelial progenitors in vitro. Research Results in Pharmacology 2(1): 58–62. https://doi.org/10.18413/2313-8971-2016-2-1-58-62

Issue

Vol. 2 No. 1 (2016)

Section

Review article

License

Copyright (c) 2016 Research Results in Pharmacology

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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