Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach

Authors

DOI:

https://doi.org/10.3897/rrpharmacology.6.49413

Abstract

Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules such as chemokines, and cytokines, cell adhesion molecules, lipid medi­ators, interleukins (IL), growth factors (GFs), hormones, micro RNAs (miRNAs), long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), exosomes, as well as microvesicles, the secretome. MSCs of various origin, including adipose-derived stem cells (ASCs), bone marrow derived mesenchymal stem cells (BM-MSCs), human uterine cervical stem cells (hUCESCs), may be good candidates for obtaining secretome-derived products. Different population of MSCs can secret different factors which could have anti-inflammatory, anti-apoptotic, anti-fibrotic activities, a neuroprotective effect, could improve bone, muscle, liver regeneration and wound healing. Therefore, the paracrine activity of condi­tioned medium obtained when cultivating MSCs, due to a plethora of bioactive factors, was assumed to have the most prominent cell-free therapeutic impact and can serve as a better option in the field of regenerative medicine in future.

Keywords:

mesenchymal stem cells, pre-conditioning, secretome, regeneration, immunomodulation, therapeutic potential

Author Contribution

Liubov A. Pokrovskaya, National Research Tomsk State University

Junior Researcher of Laboratory of Polymers and Composite Materials.

Ekaterina V. Zubareva, Belgorod State National Research University

PhD in Biology, Associate Professor of the Department of Biology.

Sergey V. Nadezhdin, Belgorod State National Research University; Research Laboratory of Cellular, Assisted Reproductive and DNA Technologies, Belgorod State National Research University

PhD in Biology, Associate Professor, Head of the Scientific Research Laboratory of Cellular, Assisted Reproductive and DNA Technologies.

Anna S. Lysenko, Belgorod State National Research University

Undergraduate student.

Tatyana L. Litovkina, Belgorod State National Research University

Undergraduate student.

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Published

30-03-2020

How to Cite

Pokrovskaya LA, Zubareva EV, Nadezhdin SV, Lysenko AS, Litovkina TL (2020) Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach. Research Results in Pharmacology 6(1): 57–68. https://doi.org/10.3897/rrpharmacology.6.49413

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Section

Review article

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