Antibiotic resistance of infectious agents associated with prior hospitalization

Authors

DOI:

https://doi.org/10.18413/rrpharmacology.10.436

Abstract

Introduction: One of the frequent causes of re-hospitalization is infectious complications due to previous colonization of patient loci by microorganisms circulating in the hospital environment. In the conditions of real clinical practice among hospital-acquired infections (HAI), it is advisable to distinguish a special group of diseases – infections associated with previous hospitalization (IPAH). Of particular scientific interest is the study of the antibiotic resistance profile of IPAH pathogens in order to determine the further strategy of empirical antibiotic therapy.

Materials and Methods: A two-center descriptive study was conducted in Tomsk region. We analyzed 170 cases of IPAH according to the medical records of patients receiving medical care in inpatient settings (form N 003/u) in the period from 2019 to 2023. Identification of microorganisms was carried out by classical bacteriological method.

Results and Discussion: Gram-negative bacteria (95.3%) predominated in the etiology of pneumonia associated with prior hospitalization. Among Gram-negative microorganisms, the most frequent were K. pneumoniae, P. aeroginosa and K. oxytoca. Representatives of the families Enterobacteriaceae (48.2%), Staphylococcaceae (28.9%) and Enterococcaceae (10.8%) predominated in the etiology of surgical infection associated with previous hospitalization. In the species structure, the key pathogens were K. pneumoniae, S. aureus and E. coli. IPAH pathogens were characterized by an unfavorable resistance profile.

Conclusion: Despite the fact that the etiological structure and antibiotic resistance profile of IPAH are similar to those of classical nosocomial infections, IPAH has important features that should certainly be taken into account when organizing medical care for this cohort of patients.

Graphical Abstract

Keywords:

antibiotic resistance, antibiotic therapy, nosocomial infections, previous hospitalization

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Author Contribution

Daria Yu. Perfileva, Siberian State Medical University

Assistant of the Department Healthcare and Public Health Management Siberian State Medical University of the Ministry of Health of the Russian Federation; e-mail: daria.perfileva@mail.ru; ORCID ID https://orcid.org/0000-0002-1168-7405. Author’s contribution: analysis and interpretation of the research results; preparation and editing of the text of the manuscript; and scientific design.

Alexander G. Miroshnichenko, South Ural State Medical University

Doctor Habilit. of Medicine, Associate Professor, Acting Rector, South Ural State Medical University of the Ministry of Health of the Russian Federation; e-mail: ag.miro@yandex.ru; ORCID ID https://orcid.org/0000-0003-4035-8341. Author’s contribution: development of the concept – conceptualization and development of the research direction; formulation of key goals and objectives.

Evgeny S. Kulikov, Siberian State Medical University

Doctor Habilit. of Medicine, Associate Professor, Rector, Siberian State Medical University of the Ministry of Health of the Russian Federation; e-mail: kulikov.es@ssmu.ru; ORCID IDhttps://orcid.org/0000-0002-0088-9204. Author’s contribution: development of the concept – conceptualization and development of the research direction; formulation of key goals and objectives.

Vyacheslav Yu. Perfilev, Siberian State Medical University

Candidate of Sciences (in Medicine), Associate Professor of the Department of Pharmacology, Siberian State Medical University of the Ministry of Health of the Russian Federation; e-mail: p.v.yu@mail.ru; ORCID ID https://orcid.org/0000-0001-6958-6423. Author’s contribution: collection, analysis and interpretation of the obtained data; preparation and drafting the manuscript.

Vadim A. Boykov, Siberian State Medical University

Doctor Habilit. of Medicine, Associate Professor, Head of the Department of Healthcare and Public Health Management, Siberian State Medical University of the Ministry of Health of the Russian Federation; e-mail: boykov85@mail.ru; ORCID ID https://orcid.org/0000-0001-7532-7102. Author’s contribution: critical revision of the manuscript with offering valuable comments.

Sofia V. Nesterovich, Siberian State Medical University

Candidate of Sciences (in Medicine), Clinic Chief Physician, Siberian State Medical University of the Ministry of Health of the Russian Federation; e-mail: snesterovich@mail.ru; ORCID IDhttps://orcid.org/0000-0003-2098-2964. Author’s contribution: critical revision of the manuscript with offering valuable comments.

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Published

09-02-2024

How to Cite

Perfileva DY, Miroshnichenko AG, Kulikov ES, Perfilev VY, Boykov VA, Nesterovich SV (2024) Antibiotic resistance of infectious agents associated with prior hospitalization. Research Results in Pharmacology 10(1): 15–21. https://doi.org/10.18413/rrpharmacology.10.436

Issue

Vol. 10 No. 1 (2024)

Section

Clinical Pharmacology

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Copyright (c) 2024 Daria Yu. Perfileva, Alexander G. Miroshnichenko, Evgeny S. Kulikov, Vyacheslav Yu. Perfilev, Vadim A. Boykov, Sofia V. Nesterovich

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