Cardiotropic medicinal products of plant origin. Prospects for use in modern clinical practice
Authors
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Nadezhda V. Nesterova
Plekhanov Russian University of Economics
https://orcid.org/0000-0002-9752-9757
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Natalia D. Bunyatyan
Institute of Research and Development of the Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products
https://orcid.org/0000-0001-9466-1261
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Irina A. Samylina
I.M. Sechenov First Moscow State Medical Universit
https://orcid.org/0000-0002-4895-0203
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Vladimir A. Evteev
Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’
https://orcid.org/0000-0002-6150-5796
DOI:
https://doi.org/10.18413/rrpharmacology.11.549Abstract
Introduction: The aim of the research was to study the current state of use and improvement of the prospects for the using cardiological medicinal products obtained on the basis of medicinal plant raw materials.
Materials and Methods: The work used content analysis, monitoring of scientific articles using the databases PubMed, Scopus, Google Scholar, ResearchGate, analysis of the nomenclature of the State Register of Medicines of the Russian Federation (2024) and the Register of Medicines of Russia (2024).
Results and Discussion: The study revealed that diseases of the cardiovascular system are some of the most common causes of death among the population, with at least 37.7 million people suffering from varying degrees of heart failure alone. Despite the constant growth of the range of medicines for the treatment of cardiovascular diseases, medicinal plants and preparations based on them, which are more often used in complex therapy, still play an important role in their therapy. In this review, we consider drugs derived from medicinal plant raw materials used for the treatment of heart failure and arrhythmia of various etiologies, as the most serious cardiovascular pathologies.
Conclusion: Preparations based on herbal remedies with cardiotropic and antiarrhythmic effects are relevant in the treatment of cardiovascular diseases. Cardiotropic action is characteristic of the group of cardiac glycosides, and antiarrhythmic activity is more pronounced in alkaloids and flavonoid substances. Taking into account the prospects for the use of herbal preparations with cardiotropic effects in the complex therapy of cardiovascular diseases, an important and unsolved problem today remains the problem of their interaction with other drugs, which in the future can be solved by creating artificial intelligence programs that contribute to the formation of optimal prescriptions for a particular patient.
Graphical Abstract
Keywords:
cardiotropic effect, antiarrhythmic effect, cardiac glycosides, alkaloids, side effects, polypharmacotherapyReferences
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