Pharmacoepidemiological analysis of drug therapy for asthenic syndrome as provided in Kaliningrad region

Authors

DOI:

https://doi.org/10.18413/rrpharmacology.11.586

Abstract

Introduction: Asthenic syndrome (AS) is increasingly prevalent, especially post-COVID, but its treatment lacks standardization due to unclear pathogenesis and diagnostic challenges. Current approaches rely on physician experience, underscoring the need for pharmacoepidemiological studies to optimize therapy.

Materials and Methods: This study analyzed AS drug therapy (ICD-10 G90.8) in Kaliningrad region. A retrospective cross-sectional study of 358 patients (82 males, 276 females) evaluated outpatient and inpatient treatment using healthcare database records. Data were processed using Microsoft Access, Excel, and Statistica 13.3, with descriptive statistics (mean, median, mode, etc.).

Results and Discussion: Showed 77% of AS patients were female, with monotherapy predominant (69.3% outpatients, 61.8% inpatients). Key drug subgroups included N07XX (48% outpatients, 66% inpatients – mainly succinic acid combinations) and N06BX (18% outpatients, 23% inpatients – primarily vinpocetine).

Conclusion: Overall, 28 ATC drug subgroups were used, with greater variety in outpatient care. Common medications were ethylmethylhydroxyperidine succinate (EMHPS) and combinations of inosine, nicotinamide, and riboflavin. The findings highlight inconsistent prescribing patterns and the need for standardized protocols to reduce polypharmacy and improve outcomes.

Graphical Abstract

Keywords:

asthenia, pharmacotherapy, pharmacoepidemiological study, real-world clinical practice

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Author Contribution

Yana D. Belousova, Immanuel Kant Baltic Federal University

Clinical Pharmacologist; Postgraduate Student; Lecturer, Department of Therapy, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad, Russia; e-mail: yana-belousova@inbox.ru; ORCID ID: https://orcid.org/0000-0001-9333-1244. Conceptualised the study, conducted the research, analysed and interpreted the results, created the tables and graphs, reviewed the literature and drafted the manuscript.

Nadezhda O. Kryukova, Immanuel Kant Baltic Federal University

Dr. Hab. of Medical Sciences, Associate Professor, Department of Fundamental Medicine, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad, Russia; mail: krukovano@yandex.ru; ORCID ID: https://orcid.org/0000‑0002‑2379‑6764. Analysed and interpreted the results, reviewed the literature, and contributed to manuscript drafting.

Iuliia A. Filimonkina , Immanuel Kant Baltic Federal University

Postgraduate student; Lecturer, Department of Therapy, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad, Russia; e-mail:filimonkina@mail.ru; ORCID ID: https://orcid.org/0009-0000-1864-2448. Analyzed the results and edited the article.

Vladimir V. Rafalskiy, Immanuel Kant Baltic Federal University; 2Clinical Trials Centre at IKBFU

Hab. of Medical Sciences, Professor, Department of Therapy, Institute of Medicine and Life Sciences (MEDBIO), Immanuel Kant Baltic Federal University, Kaliningrad, Russia; e-mail: v.rafalskiy@mail.ru; ORCID ID: https://orcid.org/0000-0002-2503-9580.  Developed the concept, edited the manuscript, and provided final approval.

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Published

27-09-2025

How to Cite

Belousova YD, Kryukova NO, Filimonkina IA, Rafalskiy VV (2025) Pharmacoepidemiological analysis of drug therapy for asthenic syndrome as provided in Kaliningrad region. Research Results in Pharmacology 11(3): 37–43. https://doi.org/10.18413/rrpharmacology.11.586

Issue

Vol. 11 No. 3 (2025)

Section

Clinical Pharmacology

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Copyright (c) 2025 Belousova YaD, Kryukova NO, Filimonkina IuA, Rafalskiy VV

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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