Studying dose-dependent endothelio- and cardioprotective activity of selective arginase II inhibitor in hyperhomocysteine-induced endothelial dysfunction

Authors

  • Vladimir I. Yakushev Yakovlevskaya central district hospital
  • Nikolaj G. Filippenko Kursk State Medical University
  • Irina V. Kizilova Yakovlevskaya central district hospital
  • Mikhail Viktorovich Korokin Belgorod State National Research University ORCID logo https://orcid.org/0000-0001-5402-0697
  • Evgeniya Beskhmelnitsyna Belgorod National Research University ORCID logo https://orcid.org/0000-0001-6009-5740
  • Anna S. Litvinova Belgorod National Research University

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-42-45

Abstract

This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the code ZB49-0010C in the model of hyperhomocysteine-induced endothelial dysfunction. The results of the studies prove the presence in the arginase II selective inhibitor, the substance under the code ZB49-0010C, dosedependent endothelioprotective and cardioprotective activity, which expression increases with the increase in dose and is maximum at a dose of 10 mg/kg. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.

Keywords:

endothelial dysfunction, a selective inhibitor of arginase II, nitric oxide, methionine, homocysteine

Author Contribution

Vladimir I. Yakushev, Yakovlevskaya central district hospital

Therapeutist of admission office of Regional State-financed health institution “Yakovlevskaya central district hospital”, Stroitel, Yakovlevsky district, Belgorod region, Russia

Nikolaj G. Filippenko, Kursk State Medical University

Doctor of Medical Sciences, Professor, Department of Clinical Pharmacology and Pharmacotherapy Kursk State Medical University, Kursk, Russia

Irina V. Kizilova, Yakovlevskaya central district hospital

Head doctor of Regional State-financed health institution “Yakovlevskaya central district hospital”, Stroitel, Yakovlevsky district, Belgorod region, Russia

Mikhail Viktorovich Korokin, Belgorod State National Research University

Doctor of medicine, professor of the pharmacological department of Medical Institute of Belgorod State National Research University, Belgorod, Russia

Evgeniya Beskhmelnitsyna, Belgorod National Research University

Postgraduate student of pharmacological department of Belgorod State National Research University, Belgorod, Russia 

Anna S. Litvinova, Belgorod National Research University

Fifth-year student of medical faculty of Belgorod State National Research University, Belgorod, Russia.

Downloads

Published

31-03-2016

How to Cite

Yakushev VI, Filippenko NG, Kizilova IV, Korokin MV, Beskhmelnitsyna E, Litvinova AS (2016) Studying dose-dependent endothelio- and cardioprotective activity of selective arginase II inhibitor in hyperhomocysteine-induced endothelial dysfunction. Research Results in Pharmacology 2(1): 42–45. https://doi.org/10.18413/2313-8971-2016-2-1-42-45

Issue

Vol. 2 No. 1 (2016)

Section

Review article

License

Copyright (c) 2016 Research Results in Pharmacology

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Most read articles by the same author(s)