Pancreatogenic infections: importance of microbiological monitoring and penetration of antimicrobial chemotherapeutic agents into the pancreas when defining therapeutic approach
DOI:
https://doi.org/10.18413/2500-235X-2015-1-4-69-72Abstract
The review provides the information on the spectrum of microorganisms initiating the development of clinical and morphological forms of pancreatogenic infections. It is shown that when analyzing pathological conditions, no features in the microbiological landscape of the secondary infection in the pancreas and the surrounding extraperitoneal cellular tissue are registered. It provides the information on the particular structure of the microorganisms spectrum in acute pancreatitis in the Italian, Mexican, Indian, Chinese and Russian patient populations. Special attention has been paid to the choice of antibacterial medications in acute pancreatitis; the choice is based on sensitivity of allocated microorganisms to these medications, and particularities of medication therapeutic concentrations formation in the pancreas tissues or its secret. Foreign researchers’ experimental and clinical data regarding the penetration degree of various antibacterial agents into pancreatic tissue in the presence of pancreatic necrosis and efficiency of the agents in the process of drug correction of necrotizing pancreatitis. The analyzed information predetermines the need for a continuous microbiological pattern monitoring on the local level in association with assessment of its sensitivity and specificity to the prescribed antibacterial therapy of acute pancreatitis in the early stages of its infectious complications.
Keywords:
pancreatic necrosis, pancreatogenic infection, antimicrobial agents, antibiotic resistance, penetration of antimicrobial agents into the pancreasReferences
Golub AV, Dekhnich AV, Kozlov RS. Antimicrobial Therapy of Complicated Intra-abdominal Infections: What does the success depend on? Clinical Microbiology and Antimicrobial Chemotherapy, 2011, No.13(2): P. 158-162.
Guchev IA, Volkov IP, Ivanov AM 2007 Pancreatic Necrosis. Antibacterial therapy and prophylaxis options. Russian Medical Journal, 2007, No.12: P. 965- 973.
Dellinger EP 2003. Pancreatitis Infectious Complications. Clinical Microbiology and Antimicrobial Chemotherapy, 2003, No.5 (2): P. 108-118.
Zubkov MN. Today’s Aspects of Antibiotic Prophylaxis and Antimicrobial Therapy of Pancreatic Infections. Farmateka, 2006, No.4: P. 2-12.
Мalorodova ТN, Аfanasiev YI, Pokrovskaya ТG et al. Microbiological flora and antibiotic therapy of infected pancreatic necrosis. Belgorod State University Scientific Bulletin. Medicine Pharmacy, 2014, No.11(182): P. 45-49.
Ragulina VA, Loktionov AL, Konoplya AI, Pokrovskiy.V, Alehin SA et al. Efficiency of 3-hydroxypiridin derivatives in correction of immune and oxydant disorders in case of experimental acute pancreatitis. Belgorod State University Scientific bulletin. Medicine Pharmacy, 2014, No.4 (123): P. 203-207.
Rudnov VA, Belsky DV, Dekhnich AV. Infections in Russian ICUs. Results of the Nationwide Multicenter Study. Clinical Microbiology and Antimicrobial Chemotherapy, 2011, No.13(4): P. 294-303.
Reshedko GK, Schebnikov AG, Morozov MV et al. Escherichia coli as agents of nosocomial infections in ICUs. Clinical Microbiology and Antimicrobial Chemotherapy, 2011, No.13(4): P. 314-321.
Reshedko GK, Ryabkov EL, Faraschuk AN et al. Non-Fermenting Gram-Negative Agents of Nosocomial Infections in Russian ICUs: Antibiotic-Resistance Problems. Clinical Microbiology and Antimicrobial Chemotherapy, 2006, No. 8 (3): P. 243-259.
Sukhorukova MV, Eidelstein MV, Skleenova EY et al. Antibiotic Resistance of Nosocomial Enterobacteriaceae Strains in Russian Hospitals: Results of the Multicenter Epidemiological Study МАRATHON in 2011–2012. Clinical Microbiology and Antimicrobial Chemotherapy, 2014, No. 16(4): P. 254-265.