Pharmacological correction of metabolic disorders in experimental acute pancreatitis on the background of chronic alcohol intoxication

Authors

DOI:

https://doi.org/10.3897/rrpharmacology.4.31594

Abstract

Introduction. Acute pancreatitis and pre-existing diseases (chronic alcohol intoxication) are challenging issues of modern surgery in terms of frequency of deaths and the number of complications.

Objective. To identify the best combination of immunomodulators, antioxidants and hepatoprotectors to correct immunometabolic disorders in acute destructive pancreatitis on the background of chronic alcohol intoxication (CAI).

Materials and methods. Studies were conducted on 377 healthy adult Wistar rats weighing 150-200 g. Alcohol intoxication was modeled by forced intragastric administration of a 20% ethanol solution at a dose of 3 ml/kg or 2.92 g/kg at 24 hours for 5 days, 30 days (CAI-30) or 60 days (CAI-60). Acute destructive pancreatitis (ADP) was modeled after R.N. Wang et al. (1995), modified by S.A. Alekhin et al. (2006). The efficacy of combining Hepon (5 mg/kg, orally, at 24 hours, No. 14), Hypoxen (750 mg/kg, orally, at 24 hours, No. 14), Phosphogliv (800 mg/kg, orally, at 24 hours, No. 14), Glutoxim (20 mg/kg, intramuscularly, at 24 hours, No. 5), Mexidol (50 mg/kg, intraperitoneally, at 24 hours, No. 14) and Heptral (760 mg/kg, intraperitoneally, at 24 hours , No. 5) was examined in animals with ADP on the background of CAI-30 and CAI-60.

Results and discussion. Different degrees of ethanol intoxication depending on time leads to the development of an impaired capacity of hepatocytes, as well as immune and metabolic disorders. The administration of Phosphogliv, Hypoxen and Hepon in case of CAI-30+ADP normalizes 12.1% and corrects 60.6% of the changed values. The combination of Heptral, Glutoxim and Mexidol normalizes 57.8% and corrects 42.4% of the values. In case of CAI-60+ADP, Phosphogliv, Hypoxen and Hepon normalizes 11.8% and corrects 38.2% of the values. The combination of Heptral, Glutoxim and Mexidol normalizes 17.6% and corrects 67.6% of the values, respectively.

Conclusion. In case of ADP along with CAI-30 and CAI-60, the combination of Heptral, Glutoxim and Mexidol is more preferable than that of Phosphogliv, Hypoxen and Hepon.

Keywords:

alcohol intoxication, metabolic disorders, pharmacological correction

Author Contribution

Olga N. Bushmina, Kursk State Medical University of the Ministry of Healthcare of the Russian Federation

Teaching assistant, Department of Biological Chemistry. The author was engaged in collecting, analyzing and interpreting data for the paper.

Svetlana A. Dolgareva, Kursk State Medical University of the Ministry of Healthcare of Russia

Doctor of Medicine, Associate Professor, Professor, Department of Biological Chemistry. The author drafted the project, carried out a critical analysis of the intellectual content.

Alexander I. Konoplya, Kursk State Medical University of the Ministry of Healthcare of Russia

Doctor of Medicine, Professor, Distinguished Academic, Head of the Department of Biological Chemistry. The author made a significant contribution to the concept and design of the paper and gave the final approval of the version to be published.

Alexey L. Loktionov, Kursk State Medical University of the Ministry of Healthcare of Russia

Doctor of Medicine, Associate Professor, Professor, Department of Surgical Diseases №2. The author prepared an agreement and a final copy of the manuscript to be sent to the editorial office. Scopus

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Published

02-12-2018

How to Cite

Bushmina ON, Dolgareva SA, Konoplya AI, Loktionov AL (2018) Pharmacological correction of metabolic disorders in experimental acute pancreatitis on the background of chronic alcohol intoxication. Research Results in Pharmacology 4(4): 9–19. https://doi.org/10.3897/rrpharmacology.4.31594

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Section

Review article