Pharmacological correction of L-name-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate

Authors

  • Sophiya Ya. Skachilova Russian scientific center for security biologically active substances
  • Oleg G. Kesarev Russian scientific center for security biologically active substances
  • Lyudmila Danilenko Belgorod National Research University
  • Natalya A. Bystrova Kursk State Medical University
  • Alexandr A. Dolzhikov Belgorod National Research University
  • Sergej B. Nikolaev St. Joasaph Belgorod Regional Clinical Hospital

DOI:

https://doi.org/10.18413/2313-8971-2016-2-1-36-41

Abstract

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have shown that 3-(2,2,2-trimethylhydrazinium) propionate and its derivatives reduced the expression of NOdeficient endothelial dysfunction induced by intraperitoneal administration of N-nitro L-arginine methyl ester (L-NAME), improved the parameters of endothelium-dependent vasodilation in response to administration of acetylcholine, and reduced the coefficient of endothelial dysfunction. It was revealed that the 5-hydroxinicotinate 3-(2,2,2-trimethylhydrazinium) potassium propionate has the most pronounced endothelioprotective effect.

Keywords:

endothelial dysfunction, 3-(2,2,2-trimethylhydrazinium) propionate, L-NAME

Author Contribution

Sophiya Ya. Skachilova, Russian scientific center for security biologically active substances

Doctor of Сhemical Sciences, head of laboratory of chemistry and technology of synthetic drugs "Russian scientific center for security biologically active substances" (JSC "all-Russian scientific centre BAS"), Moscow region, Noginsk district, Staraya Kupavna, Russia 

Oleg G. Kesarev, Russian scientific center for security biologically active substances

PhD in Chemical Sciences, head the sector of technology of synthesis substances "Russian scientific center for security biologically active substances" (JSC "all-Russian scientific centre BAS"),
Moscow region, Noginsk district, Staraya Kupavna, Russia

Lyudmila Danilenko, Belgorod National Research University

PhD in Pharmaceutical Sciences, Associate Professor of the Department of Pharmacology, Belgorod National Research University, Belgorod, Russia

Natalya A. Bystrova, Kursk State Medical University

Doctor of Medical Sciences, Professor Department of biochemistry of Kursk State Medical University,
Kursk, Russia

Alexandr A. Dolzhikov, Belgorod National Research University

Doctor of Medical Sciences, Professor Department of histology of Medical Institute of Belgorod State National Research University, Belgorod, Russia

Sergej B. Nikolaev, St. Joasaph Belgorod Regional Clinical Hospital

Doctor of Medical Sciences, St. Joasaph Belgorod Regional Clinical Hospital, Belgorod, Russia

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Published

31-03-2016

How to Cite

Skachilova SY, Kesarev OG, Danilenko L, Bystrova NA, Dolzhikov AA, Nikolaev SB (2016) Pharmacological correction of L-name-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate. Research Results in Pharmacology 2(1): 36–41. https://doi.org/10.18413/2313-8971-2016-2-1-36-41

Issue

Vol. 2 No. 1 (2016)

Section

Review article

License

Copyright (c) 2016 Research Results in Pharmacology

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This work is licensed under a Creative Commons Attribution 4.0 International License.