Патоморфологическая оценка состояния тканей десны при применении композиции геля Содерм®-Форте с Цитофлавином® в условиях экспериментального пародонтита у крыс

Авторы

DOI:

https://doi.org/10.18413/rrpharmacology.9.10017

Аннотация

Введение: Пародонтит – одна из наиболее актуальных проблем в современной стоматологии. Разработка новых подходов и схем комплексного лечения пациентов с пародонтитом является стратегической задачей фармакологов и стоматологов. В этом аспекте патоморфологические исследования занимают важное место, так как позволяют с высокой объективностью судить о лечебной эффективности применяемых лекарственных средств.

Цель исследования: оценить характер влияния композиции Содерм®-Форте и Цитофлавина® на патоморфологическое состояние тканей десны при экспериментальном пародонтите (ЭП) у крыс.

Материалы и методы: ЭП моделировали у крыс лигатурным методом. Алгоритм исследования: животные без ЭП; с ЭП без лечения; с ЭП и традиционной медикаментозной терапией (ТМТ); с ЭП, ТМТ и Содерм®-Форте; с ЭП, ТМТ, Содерм®-Форте и Цитофлавином®. Биопсийный материал для патоморфологических исследований брали из десны пришеечной области нижних резцов. Микропрепараты окрашивали гематоксилином и эозином, а также по Массону. Компьютерную морфометрию проводили с использованием программы «ImageJ».

Результаты: При ЭП применение ТМТ оказывает умеренное положительное воздействие на патоморфологические изменения в десне. Композиция ТМТ с Содерм®-Форте и более значимо ТМТ с Содерм®-Форте и Цитофлавином® обладают высокой лечебной эффективностью, характеризующейся быстрым восстановлением тканевых структур десны.

Заключение: Композиция ТМТ с Содерм®-Форте и Цитофлавином® при ЭП оказывает более выраженное терапевтическое воздействие, проявляющееся ранним купированием патологических процессов и ускорением регенерации тканей в десне.

Графическая аннотация

Ключевые слова:

Soderm®-Forte gel, computer morphometry, pathomorphological changes in gum tissue, Cytoflavin®, experimental periodontitisУдалить experimental periodontitis

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Вклад авторов

Павел А. Галенко-Ярошевский, Кубанский государственный медицинский университет

Сorresponding member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Head of the Department of Pharmacology of Kuban State Medical University, Krasnodar, Russia; Senior Research Scientist of Research Institute for the Pharmacology of Living Systems of Belgorod State National Research University, Belgorod, Russia; е-mail: Galenko.Yaroсhevsky@gmail.com; ORCID ID https://orсid.org/0000-0001-6856-1777. The author’s contribution: concept development – conceptualization and direction development of the research; generation of the key aims and objectives.

Александр А. Славинский, Кубанский государственный медицинский университет

Holder of an Advanced Doctorate (Doctor of Science) in Biological Sciences, Professor, Head of the Department of Pathological Anatomy of Kuban State Medical University, Krasnodar, Russia; е-mail: al-slavinsky@mail.ru; ORCID ID https://orcid.org/0000-0001-9824-9186. The author’s contribution: defining the key aims and objectives; interpretation of the data obtained; critical revision of the manuscript and provision of valuable comments.

Марк А. Задорожный, Ростовский государтсвенный медицинский университет

Postgraduate student of the Department of Dentistry No.1 of Rostov State Medical University, Rostov-on-Don, Russia; e-mail: markys-97@yandex.ru; ORCID ID https://orcid.org/0000-0002-7528-6109. The author’s contribution: experimentation – collection, analysis and interpretation of the data obtained; drafting the manuscript.

Валерий К. Леонтьев, Московский государственный медико-стоматологический университет имени А.И. Евдокимова

Member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia; Vice-President of the Dental Association of Russia, Honored Scientist of the Russian Federation, laureate of the State Prize of the Russian Federation in Science and Technology; e-mail: LeontyevVK@mail.ru; ORCID ID https://orcid.org/0000-0003-2296-8904. The author’s contribution: approval of the final stage of the article preparation – admission of responsibility for all stages of the research, the integrity of the article and its final draft.

Артур В. Хейгетян, Ростовский государственный медицинский университет

PhD in Medical Sciences, Associate Professor, Head of the Department of Dentistry No.1 of Rostov State Medical University, Rostov-on-Don, Russia; e-mail: artur5953@yandex.ru; ORCID ID https://orcid.org/0000-0002-8222-4854. The author’s contribution: concept development – conceptualization and direction development of the research; generation of the key aims and objectives.

Виктор Л. Попков, Кубанский государственный медицинский университет

Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Department of Orthopedic Dentistry of Kuban State Medical University, Krasnodar, Russia; e-mail: popkoff2015@yandex.ru; ORCID ID https://orcid.org/0000-0001-7362-0073. The author’s contribution: development and design of methodology, defining the key aims and objectives, critical revision of the manuscript and provision of valuable comments.

Анаит В. Зеленская, Кубанский государственный медицинский университет

PhD in Medical Sciences, Associate Professor of the Department of Pharmacology of Kuban State Medical University, Krasnodar, Russia; е-mail: anait_06@mail.ru; ORCID ID https://orcid.org/0000-0001-9512-2526. The author’s contribution: analysis and interpretation of research results; preparing and editing the article text; participation in the scientific design.

Людмила М. Чуприненко, Кубанский государственный медицинский университет

PhD in Medical Sciences, Associate Professor of the Department of Pathological Anatomy of Kuban State Medical University, Krasnodar, Russia; e-mail: lmchbox@mail.ru; ORCID ID https://orcid.org/0000-0002-2770-3529. The author’s contribution: pathomorphological analysis, analysis and interpretation of research results

Александр А. Веревкин, Кубанский государственный медицинский университет

PhD in Medical Sciences, Associate Professor of the Department of Pathological Anatomy of Kuban State Medical University, Krasnodar, Russia; e-mail: vilehand@bk.ru; ORCID ID https://orcid.org/0000-0002-4159-2618. The author’s contribution: computer morphometry, analysis and interpretation of the research results.

Изабелла Г. Ломсадзе, Кубанский государственный медицинский университет

3rd year undergraduate student of the Department of General Medicine of Kuban State Medical University, Krasnodar, Russia; e-mail: izabella.lomsadze@yandex.ru; ORCID ID https://orcid.org/0009-0007-5584-3397. The author’s contribution: literature search, pathomorphological analysis.

Мария Ю. Матеренчук, Первый московсий государственный медицинский университет им И.М. Сеченова

4rd year undergraduate student majoring in Medical Biochemistry at Institute of Biodesign and Complex System Modelling of I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: mariamatter231@gmail.com; ORCID ID https://orcid.org/0000-0002-0711-4153. The author’s contribution: graphic design and visualization of study design.

Светлана А. Лебедева, Первый московский государственный медицинский университет им И.М. Сеченова

Holder of an Advanced Doctorate (Doctor of Science) in Biological Sciences, Professor of the Department of Pharmacology of Institute of Pharmacy of I.M. Sechenov First Moscow State Medical University, Moscow, Russia; e-mail: Lebedeva502@yandex.ru; ORCID ID https://orcid.org/0000-0003-0325-6397. The author’s contribution: defining the key aims and objectives; critical revision of the manuscript and provision of valuable comments.

Загрузки

Опубликован

19.04.2023

Как цитировать

Galenko-Yaroshevsky PA, Slavinskiy AА, Zadorozhniy MA, Leontev VK, Kheigetyan AV, Popkov VL, Zelenskaya AV, Chuprinenko LM, Verevkin AА, Lomsadze IG, Materenchuk MY, Lebedeva SA (2023) Pathomorphological analysis of the gum tissues in the application of the combination of Soderm®-Forte gel with Cytoflavin® in experimental periodontitis in rats. Research Results in Pharmacology 9(2): 1–10. https://doi.org/10.18413/rrpharmacology.9.10017

Выпуск

Том 9 № 2 (2023)

Раздел

Экспериментальная фармакология