Diabetic foot syndrome: importance of microbiological monitoring and antimicrobial penetration of chemotherapeutic agents into the soft tissue lower limb in determining the treatment

Авторы

  • Tatyana N. Malorodova St. Joseph Belgorod Regional Clinical Hospital
  • Tatyana Grigoryevna Pokrovskaya Belgorod National Research University ORCID logo https://orcid.org/0000-0001-6802-5368
  • Elena E. Kazakova St. Joseph Belgorod Regional Clinical Hospital
  • Zhanna Urozhevskaya Belgorod State National Research University

Аннотация

Foot infections are a common and serious problem in persons with diabetes. Persistent ulcers in patients with diabetic foot syndrome in 85% of cases lead to amputation because of secondary infection and growing gangrene that significantly worsen the prognosis. The review provides the information on the spectrum of microorganisms, initiating the development of clinical and morphological forms of diabetic foot infections. Special attention has been paid to the choice in diabetic foot infections antibacterial medications based on indicators of sensitivity to them by allocated microorganisms and features of therapeutic concentrations formation in the skin, soft tissues or bone. Clinical data of researchers in the degree of penetration of various antibacterial agents in soft tissue and depend on severity lesions. In our review, it was shown that the most common pathogen was Staphylococcus aureus, followed by Pseudomonas aeruginosa, Enterobacteriaceae: E. coli, Proteus spp., Klebsiella pneumoniae, Enterobacter spp., and Acinetobacter spp. due to multidrug-resistant organisms, such as extended-spectrum betalactamase-producing Gram-negative rods or methicillin-resistant Staphylococcus aureus have emerged as substantial problem. Data on the frequency and the sensitivity of key pathogens in diabetic foot differ in Russian and foreign researchers, which causes the necessary treatment considering local peculiarities allocated pathogens and the degree of penetration of anti-infective agents in the affected tissues.

Ключевые слова:

diabetic foot syndrome, infection, antibiotics, antibiotic resistance, tissue penetration of antibiotic

Вклад авторов

Tatyana N. Malorodova, St. Joseph Belgorod Regional Clinical Hospital

Clinical pharmacologist of department of clinical pharmacology of St. Joseph Belgorod Regional Clinical Hospital, Belgorod, Russia 

Tatyana Grigoryevna Pokrovskaya, Belgorod National Research University

Doctor of Medical Sciences, Professor; Department of pharmacology of Belgorod State National Research University,  Belgorod, Russia
Scopus

Elena E. Kazakova, St. Joseph Belgorod Regional Clinical Hospital

Deputy head physician at the medical unit of St. Joseph Belgorod Regional Clinical Hospital, Honored Doctor of the Russian Federation, Belgorod, Russia 

Zhanna Urozhevskaya, Belgorod State National Research University

Intern of the Department of Pediatrics with a course of pediatric surgery of Belgorod State National Research University, Belgorod,  Russia

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Опубликован

28.06.2016

Как цитировать

Malorodova TN, Pokrovskaya TG, Kazakova EE, Urozhevskaya Z (2016) Diabetic foot syndrome: importance of microbiological monitoring and antimicrobial penetration of chemotherapeutic agents into the soft tissue lower limb in determining the treatment. Research Results in Pharmacology: 91–98

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