The study of osteoprotective properties of nanoparticulated forms of resveratrol and losartan

Авторы

  • N.Yu Koklina Kursk State Medical University
  • O.S. Gudyrev Belgorod State National Research University
  • A.V. Faitelson Kursk State Medical University

DOI:

https://doi.org/10.18413/2500-235X-2015-1-4-32-38

Аннотация

The study demonstrated that endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone developed eight weeks after ovariectomy in female white Wistar rats thus raising the risk of generalized osteoporosis. Nanoparticulated forms of losartan and resveratrol possessing endothelioprotective action effectively prevented reduction of regional microcirculation in bone tissue through keeping it at the same level as intact rats had. It allowed maintaining an adequate level of bone remodeling processes which was manifested in slowing of thinning of bone trabeculas and in prevention of possible microfractures in them.

Ключевые слова:

osteoporosis, endothelial dysfunction, bivalos, losartan, resveratrol

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Вклад авторов

N.Yu Koklina, Kursk State Medical University

Assistant of the Department of Traumatology and Orthopedics

O.S. Gudyrev, Belgorod State National Research University

PhD in Medical Sciences, Associate Professor of the Department of Pharmacology

A.V. Faitelson, Kursk State Medical University

Doctor of Medical Sciences, Associate Professor of the Department of Traumatology and Orthopedics

Загрузки

Опубликован

30.12.2015

Как цитировать

Koklina N, Gudyrev O, Faitelson A (2015) The study of osteoprotective properties of nanoparticulated forms of resveratrol and losartan. Research Results in Pharmacology 1(1): 28–33. https://doi.org/10.18413/2500-235X-2015-1-4-32-38

Выпуск

Раздел

Экспериментальная фармакология