The study of osteoprotective properties of nanoparticulated forms of resveratrol and losartan
DOI:
https://doi.org/10.18413/2500-235X-2015-1-4-32-38Аннотация
The study demonstrated that endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone developed eight weeks after ovariectomy in female white Wistar rats thus raising the risk of generalized osteoporosis. Nanoparticulated forms of losartan and resveratrol possessing endothelioprotective action effectively prevented reduction of regional microcirculation in bone tissue through keeping it at the same level as intact rats had. It allowed maintaining an adequate level of bone remodeling processes which was manifested in slowing of thinning of bone trabeculas and in prevention of possible microfractures in them.
Ключевые слова:
osteoporosis, endothelial dysfunction, bivalos, losartan, resveratrolБиблиографические ссылки
Benevolenskaya L. I. Guidelines on Osteoporosis. М.: BINOM. Knowledge Laboratory. 2003. 524 p.
Galagan М. Е., Shirokolova А. V., Vanin А. F. The antihypertensive effect of nitric oxide produced from exogenous and endogenous sources. Questions of Med. Chem. Vol. 37, № 1. (1991): P. 67-70.
Markov, Х.М. Oxidative stress and endothelial dysfunction. Patol. Phys. and Exp. Ther. Vol. 4. (2005): P. 5-9.
Pokrovsky М.V., Pokrovskaya Т.G., Kochkarov V.I. et al. Pat. 2301015 Russian Federation, MPK7 А61В 5/02. A method of evaluating endothelial dysfunction / applicants and patent holders Pokrovsky М.V., Pokrovskaya Т.G., Kochkarov V.I. № 2005113243/14; petition 04.05.2005; publ. 20.06.07, Bull. 17. 7 p.: ill.
Korokin М.V., Pokrovsky М.V., Artyushkova Е.B. et al. Methods of experimental modeling of endothelial dysfunction. Allergology and immunology. Vol. 9, № 3 (2008): P. 327.
Faitelson А. V., Gudyrev О. S., Dubrovin G. М. et al. Pat. 62505 Russian Federation, МPК7 А61В 17/68. Cannulated rod-conductor for experimental measurements / applicants and patent holders Faitelson А.V., Gudyrev О.S. № 2006144474/22; petition 13.12.06; publ. 27.04.07, Bull. 12. 3 p.: ill.
Faitelson А. V., Gudyrev О. S., Dubrovin G. М. et al. Pat. 62512 Russian Federation, МPК7 А61D 3/00. Table for surgical procedures on small laboratory animals / applicants and patent holders Faitelson А.V., Gudyrev О.S. № 2006144475/22; petition 13.12.06; publ. 27.04.07, Bull. 12. 4 p.: ill.
Faitelson А.V., Gudyrev О.S., Pokrovsky М.V. et al. Vascular endothelium of bone as a target of pharmacological effects in experimental osteoporosis. Kuban Research Medical Gazette. Vol. 5 (110) (2009): P. 116-121.
Kochkarov V.I., Pokrovsky М.V., Korneev М.М. et al. Endothelioprotective effects of resveratrol and its combination with enalapril and losartan in experimental modeling of deficiency of nitric oxide. Kuban Research Medical Gazette. Vol. 9 (90). (2006): P. 150-152.
Alagiakrishnan K., Juby A., Hanley D. et al. Role of vascular factors in osteoporosis. J. Gerontol. A Biol. Sci. Med. Sci. Vol. 58 (2003): P. 362-366.
Burkhardt R., Kettner G., Bohm W. et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study. Bone. Vol. 8. (1987): P. 157-164.
Childs, S.G. Osteonecrosis: death of bone cells. Orthop. Nurs. Vol. 24. (2005): P. 295-301.
Haigh J.J., Gerber H.P., Ferrara N. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development. Vol. 127. (2000): P. 1445-1453.
Chu T.W., Wang Z.G., Zhu P.F. et al. Effect of vascular endothelial growth factor in fracture healing. Zhongguo Xiu Fu Chong Jian Wai KeZaZhi. Vol. 16 (2002): P. 75-78.
Yao Z., Lafage-Proust M.H., Plouet J. et al. Increase of both angiogenesis and bone mass in response to exercise depends on VEGF. J. Bone. Miner. Res. Vol. 19 (2004): P. 1471-1480.
Laursen J. B., Rajagopalan S., Galis Z. Role of superoxide in angiotensin II–induced but not catecholamine-induced hypertension. Circulation, Vol. 95 (1997): P. 588-593.
Lazzarini L., De Lalla F., Mader J.T. Long Bone Osteomyelitis. Curr. Infect. Dis. Rep. Vol. 4 (2002): P. 439-445.
Alagiakrishnan K., Juby A., Hanley D. et al. Role of vascular factors in osteoporosis. J. Gerontol. A Biol. Sci. Med. Sci. Vol. 58 (2003): P. 362-366.