Synthesis, characterization and biological and immunological evaluation of heterocyclic 4‑aminoantipyrine derivatives

Аннотация

Introduction: Impairment of the erectile component of the copulatory cycle represents a significant clinical and social problem, substantially reducing the quality of life in men. The highest incidence of this pathology is observed in male patients over 50 years of age, which is associated with an age-related decrease in gonadal hormonal function. In the present paper, the results of experimental studies evaluating the efficacy of co-administration of Siberian fir polyprenols and Panax ginseng in a model of copulatory function impairment caused by androgen deficiency are demonstrated.

Materials and Methods: The focus of the study was a herbal preparation being a pharmaceutical composition of Siberian fir polyprenols and Panax ginseng. The experiment was conducted in 26 sexually mature category-I male SD rats (Sprague Dawley with body weight of 250-300 g and aged 12 weeks). Siberian fir polyprenols were administered at a dose of 23 mg/kg combined with Panax ginseng at a dose of 1.5 ml/kg. The treatment course duration was 7 days. Tribestan (Sofarma, Bulgaria) at a dose of 70 mg/kg was used as a reference drug. Reduction in copulatory activity caused by androgen deficiency was modeled by administering synestrol to male rats. The level of copulatory activity was assessed by the paired sexual behavior test.

Results and Discussion: The results of experimental studies showed that the administration of synestrol to male rats led to the suppression of their copulatory activity. The groups of animals receiving Siberian fir polyprenols and Panax ginseng against the background of synestrol administration exhibited a statistically significant increase in the number of animals with rising copulatory activity (the number of mating attempts increased, and cases of ejaculation were reported). The pharmacological activity of the reference drug Tribestan was manifested at the level of tendencies.

Conclusion: The present paper demonstrates that Siberian fir polyprenols (dosed at 23 mg/kg) in combination with Panax ginseng tincture (dosed at 1.5 ml/kg) prove effective in stimulating the copulatory activity of male rats under conditions of androgen deficiency.

Графическая аннотация