Potential drug-drug interactions in the psychiatric hospital: Frequency analysis

Авторы

DOI:

https://doi.org/10.3897/rrpharmacology.5.39681

Аннотация

Introduction: Drug-drug interactions are an important clinical problem in pharmacotherapy. This study is focused on different types of drugs used in a psychiatric hospital.

Materials and methods: The pharmacoepidemiological study included the analysis of medical records of 500 psychiatric inpatients. The patients were divided into 2 groups: under 65 and over 65 years of age. All the drug prescriptions were analyzed to identify the combinations of drugs that can induce drug-drug interactions and determine their clinical significance.

Results and discussion: Over 77% of hospitalized patients were administered drug combinations that could induce drug-drug interactions, most of which were of moderate clinical significance. A reliable association was found between the patient’s age, the clinical significance of drug-drug interactions, and the pharmacotherapy structure. The most common irrational drug combinations were identified.

Conclusion: Timely analysis of drug prescriptions for potential drug-drug interactions can enhance the safety of pharmacotherapy and decrease the risk of adverse drug reactions in the psychiatric inpatient setting.

Ключевые слова:

adverse drug reactions, drug-drug interactions, pharmacotherapy safety

Вклад авторов

Oleg O. Kirilochev, Astrakhan State Medical University

PhD of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology.

Inna P. Dorfman, Astrakhan State Medical University

PhD of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology.

Adelya R. Umerova, Astrakhan State Medical University

Doctor of Medical Sciences, Head of the Department of Clinical Pharmacology.

Svetlana E. Bataeva, Astrakhan State Medical University

PhD of Medical Sciences, Associate Professor of the Department of Clinical Pharmacology.

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Опубликован

12.12.2019

Как цитировать

Kirilochev OO, Dorfman IP, Umerova AR, Bataeva SE (2019) Potential drug-drug interactions in the psychiatric hospital: Frequency analysis. Research Results in Pharmacology 5(4): 1–6. https://doi.org/10.3897/rrpharmacology.5.39681

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