Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector

Авторы

DOI:

https://doi.org/10.3897/rrpharmacology.7.73051

Аннотация

Selenium is an essential component of more than two dozen enzymes and other selenoproteins that play critical roles in reproduction, DNA synthesis, thyroid hormone metabolism, and protection from oxidative damage and infection. Selenium has a protective action against some forms of cancer and cardiovascular diseases, modulates levels of inflammatory mediators, promotes to maintain bone homeostasis and protects against bone loss. Selenium significance as a cardioprotective agent may be associated not only with its antioxidant properties, but also with its ability to prevent inflammation, autophagy, as well as the intrinsic and extrinsic apoptosis pathways. Signaling pathways, such as p-AMPK, PARP, Nrf2, STAT, are involved in the protective effects of selenium. Selenium protects against cardiovascular damage by increasing the survival rate of cardiomyocytes, including a mitochondria-dependent pathway and autophagy through peroxisome proliferator-activated receptors. Research demonstrating neuroprotective and cardioprotective effects of selenium preparations – selenoline, selenocysteine and selenomethionine – is growing at a rapid rate. It has been established that these compounds are able to normalize the levels of heat shock proteins (HSP70), which limit the cytotoxic effects of free radicals, produce energotropic action, prevent a decrease in the membrane mitochondria charge, and the opening of the mitochondrial pore. Also regulate the expression of transmembrane factors NF-kB, c-fos, which is associated with their main biological function of chaperone proteins, providing protection of neurons from damage. In this review, we want to emphasize pharmacological role of Selenium and its derivatives on human health is very complex and has yet to be fully understood.

Ключевые слова:

selenium, heat shock proteins, cardioprotective, neuroprotective, antioxidant action

Вклад авторов

Igor F. Belenichev, Zaporizhzhia State Medical University

Dr. habil. of Biology, Full Professor, head at the Department of Pharmacology and Medical Formulation with Course of Normal Physiology, Zaporizhzhia State Medical University, e-mail: ifb1914@mail.ru, ORCID ID https://orcid.org/0000-0003-1273-5314. The author of the work concept and design of the article was responsible for critical review and final approval of the article.

Nadia O. Gorchakova, Bogomolets National Medical University

Dr. habil. of Medicine, Full Professor, Bogomolets National Medical University, e-mail: gorchakova.na21@gmail.com, ORCID ID https://orcid.org/0000-0002-7240-5862. The author gave critical review and the final approval of the version to be submitted.

Nina V. Bukhtiyarova, Zaporizhzhia State Medical University

PhD of Medicine, Assistant Professor, Zaporizhzhia State Medical University, e-mail: hce.181901@gmail.com, ORCID ID https://orcid.org/0000-0003-3499-3111.Theauthor was engaged in collection, analysis and interpretation of the data for publication, and in writing the article.

Iryna B. Samura, Zaporizhzhia State Medical University

 PhD of Medicine, Assistant Professor, Zaporizhzhia State Medical University, e-mail: pea.160119@gmail.com, ORCID ID https://orcid.org/0000-0001-5352-3209. The author was engaged in collection, analysis and interpretation of the data for publication, and in their of the data critical review.

Natalia V. Savchenko, Bogomolets National Medical University

PhD of Medicine , Assistant Professor, Bogomolets National Medical University, e-mail: zhc.9416@gmail.com, ORCID ID https://orcid.org/0000-0003-3392-6638. The author was engaged in collection, analysis and interpretation of the data for publication, and in their of the data critical review.

Olena O. Popazova, Zaporizhzhia State Medical University

Teaching assistant, Master of Biology, Zaporizhzhia State Medical University, e-mail: popazova.ea@gmail.com, ORCID ID https://orcid.org/0000-0001-7740-460X. The author was engaged in collection, analysis and interpretation of the data for publication, and in their of the data critical review.

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Опубликован

03.12.2021

Как цитировать

Belenichev IF, Gorchakova NO, Bukhtiyarova NV, Samura IB, Savchenko NV, Popazova OO (2021) Pharmacological properties of selenium and its preparations: from antioxidant to neuroprotector. Research Results in Pharmacology 7(4): 29–40. https://doi.org/10.3897/rrpharmacology.7.73051

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