Study of the influence of L-norvaline, rosuvastatin and their combination on the level of microcirculation in bone tissue in experimental osteoporosis and fractures on its background

Authors

  • Samuel Densingh Vasanthi Orthopedic Hospital
  • Oleg S. Gudyrev Vasanthi Orthopedic Hospital
  • Alexander V. Faitelson Kursk State Medical University
  • Aleksandr A. Stepchenko Kursk State Medical University
  • Alexandr A. Dolzhikov Belgorod National Research University

Abstract

The experiment was carried out in female white Wistar rats to investigate the effect of L-norvaline, rosuvastatin and their combination on parameters of blood supply to the bone tissue on models of experimental osteoporosis and osteoporotic fractures. It was found that the studied drugs prevent reduction of microcirculation in osteoporotic bone tissue as well as in callus tissue of experimental osteoporotic fractures and it positively influences the course of reparative regeneration of bone tissue.

Keywords:

osteoporosis, osteoporotic fracture, microcirculation, endothelial dysfunction, L-norvaline, rosuvastatin

Author Contribution

Samuel Densingh, Vasanthi Orthopedic Hospital

PhD in Medical Sciences, Orthopedic Consultant. Vasanthi Orthopedic Hospital Razack Garden main road, Chennai, India

Oleg S. Gudyrev, Vasanthi Orthopedic Hospital

PhD in Medical Sciences, Orthopedic Consultant. Vasanthi Orthopedic Hospital Razack Garden main road, Chennai, India

Alexander V. Faitelson, Kursk State Medical University

Doctor of Medical Sciences, Associate Professor. Department of Traumatology and Orthopedics, Kursk State Medical University, Kursk, Russia

Aleksandr A. Stepchenko, Kursk State Medical University

Doctor of Medical Sciences, Professor. Department of Internal Medicine of FPE. Kursk State Medical University, Kursk, Russia

Alexandr A. Dolzhikov, Belgorod National Research University

Doctor of Medical Sciences, Professor. Immunohistochemical laboratory. Belgorod State National Research University, Belgorod, Russia.

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Published

31-03-2016

How to Cite

Densingh S, Gudyrev OS, Faitelson AV, Stepchenko AA, Dolzhikov AA (2016) Study of the influence of L-norvaline, rosuvastatin and their combination on the level of microcirculation in bone tissue in experimental osteoporosis and fractures on its background. Research Results in Pharmacology 2(1): 20–24

Issue

Vol. 2 No. 1 (2016)

Section

Review article

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