Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression
Authors
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Mahardian Rahmadi
Universitas Airlangga
https://orcid.org/0000-0002-7256-2446
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Chrismawan Ardianto
Universitas Airlangga
https://orcid.org/0000-0003-3713-7900
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Ahmad Dzulfikri Nurhan
Universitas Airlangga
https://orcid.org/0000-0001-9584-0667
- Rafiqa Amalia Chasanah Universitas Airlangga
- Dewi Islamiah Krismonika Universitas Airlangga
- Arina Dery Puspitasari Universitas Airlangga
- Budi Suprapti Universitas Airlangga; Universitas Airlangga Teaching Hospital
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Santhra Segaran
Universiti Putra Malaysia; Management & Science University
https://orcid.org/0000-0002-9756-3074
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Chia-Wei Phan
University of Malaya
https://orcid.org/0000-0003-1373-1374
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Junaidi Khotib
Universitas Airlangga
https://orcid.org/0000-0002-8468-8441
DOI:
https://doi.org/10.3897/rrpharmacology.8.82242Abstract
Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl is a common laxative used to treat constipation. To date, the effects of bisacodyl on AQP3 and AQP4 expression and the role this interaction plays in constipation are unclear. This study aimed to determine the effects of bisacodyl on AQP3 and AQP4 expression in mice after induction of constipation with morphine.
Materials and methods: The laxative effects of bisacodyl on both acute and chronic morphine-induced constipation were determined. Fecal water content, colonic bead expulsion, and colonic mRNA levels for AQP3 and AQP4 mRNA were measured.
Results and discussion: The administration of morphine to mice resulted in decreased fecal water content, longer bead expulsion times, and increased AQP3 and AQP4 mRNA levels in the colon. Meanwhile, bisacodyl administration prevented the morphine-induced changes in fecal water content, bead expulsion time, and AQP3 and AQP4 mRNA levels in the colons of mice.
Conclusion: This study suggests that bisacodyl may prevent morphine-induced constipation by preventing morphine-induced increases in AQP3 and AQP4 expression in the colon.
Graphical abstract:
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