Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute Carrageenan-induced Paw Inflammation Model

Авторы

DOI:

https://doi.org/10.3897/rrpharmacology.5.33233

Аннотация

Introduction: Evaluation of anti-inflammatory action of Codelac® Broncho with Thymus Serpyllum (elixir) in com-parison with Fenspiride was carried out on the model of acute carrageenan inflammation of the paws in rats.

Materials and methods: Edema was caused by subplantar injection of 0.1 ml of 1% λ- carrageenan gel into the hind paw. The severity of edema was assessed by using 37140 plethysmometer (UGO BASILE, Italy). The measurements were performed before edema induction and 1, 2, 4, 12, 24, 48, 72, 96 and 120 hours afterwards. Anti-inflammatory activity of the drugs was also evaluated based on the analysis of rats’ blood, C-reactive protein concentration and his- tological examination results.

Results and discussion: A decrease in the paw volume increment was revealed in the group with the studied drug incomparison with the group with the carrageenan edema model (control) 4, 12, 24 hours after injection of carrageenan (p<0.05). As a result of plethysmometry, a more pronounced anti-inflammatory effect of the studied drug than that of Fenspiride was revealed. There was a significant decrease in the levels of leukocytes (p<0.05), lymphocytes (p<0.05), monocytes (p<0.05) and neutrophils (p<0.05) in the group with the studied drug compared to those the the control

48 hours after the initiation of edema, while in the group with Fenspiride, there was only a decrease in the levels of leukocytes (p<0.05) and lymphocytes (p<0.05). There were no differences in the concentration of C-reactive protein between the groups.

Conclusion: The obtained data indicate a more pronounced anti-inflammatory activity of Codelac® Broncho with Thymus Serpyllum in comparison with Fenspiride, on the model of acute carrageenan inflammation of the paw in rats.

Ключевые слова:

Codelac® Broncho with Thymus Serpyllum (elixir), anti-inflammatory activity, carrageenan edema, acute exudative inflammation

Вклад авторов

Pavel D. Kolesnichenko, I. Mechnikov Research Institute for Vaccines and Sera

PhD in Medicine, Associate Professor.

Anna A. Peresypkina, Mechnikov Research Institute for Vaccines and Sera

PhD in Biology, Associate Professor.

Artem A. Poromov, I. Mechnikov Research Institute for Vaccines and Sera

PhD in Biology, senior researcher.

Elena N. Kareva, Pirogov Russian National Research Medical University

Doctor of Medical Sciences, Professor.

Alexey V. Tverskoi, Mechnikov Research Institute for Vaccines and Sera

PhD in Medicine, Associate Professor.

Alexey N. Demidenko, Mechnikov Research Institute for Vaccines and Sera

PhD in Medicine, Senior Lecturer.

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Опубликован

27.03.2019

Как цитировать

Kolesnichenko PD, Peresypkina AA, Poromov AA, Kareva EN, Tverskoi AV, Demidenko AN (2019) Study to Investigate the anti-inflammatory effect of Codelac® Broncho with Thymus Serpyllum (elixir) in comparison with reference drug Fenspiride (syrup) using accute Carrageenan-induced Paw Inflammation Model. Research Results in Pharmacology 5(1): 45–52. https://doi.org/10.3897/rrpharmacology.5.33233

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