Effect of pharmacological preconditioning with incretinomimetics exenatide and vildagliptin on the survival of ischemic tissues

Авторы

  • Alla P. Tarasova Belgorod State National Research University
  • Lyudmila M. Danilenko Belgorod State National Research University
  • Lev N. Sernov Belgorod State National Research University

Аннотация

Introduction: Currently, much attention is paid to the pleiotropic effects of entretenimiento.

Purposes: Study of the protective effect exenatide and valdiation with pharmacological correction of ischemic myocardial damage, damage of liver and skin graft during the experiment.

Methods: During the experimental study we used a comprehensive approach to the study of the antiischemic effects of entretenimento: doksorubitsinola model of cardiomyopathy, hypo/reperfusion of the isolated heart, ischemia/reperfusion of the liver and the modeling of the skin flap on the supply leg.

Results and discussion: Exenatide (10 mcg/kg/day) and vildagliptin (0.2 mg/kg/day) demonstrate a cardioprotective effect on doxorubicinol model of pathology that is reflected in the decline in the rate of diastolic dysfunction (StТТI), respectively, to 5.3±0.1 standard units. and 6.5±0.2 standart units in comparison with the control group 8.3±0.1 standart units in the model hypo/reperfusion of the isolated hearts of rats, exenatide (10-6 mol/l) and vildagliptin (10-4 mol/l), prevent the decrease of left ventricular pressure (LG). Exenatide (10 μg/kg) and vildagliptin (0.2 mg/kg) prevent necrotization of the skin flap 1.5 and 1.3 times in comparison with the control group. In the model of ischemia/reperfusion of the liver exenatide possess dose related hepatoprotective effect. All protective effects of entretenimiento leveled combined with a blocker of ATP-sensitive potassium channels glibenclamide (0.4 mg/kg).

Conclusion: During the study it was found that exenatide dose of 10 μg/kg/day and vildagliptin dose of 0.2 mg/kg, have a pronounced cardioprotective, hepatoprotective, and a pronounced cytoprotective effect on a model of isolated skin flap on the supply leg. ATP-dependent potassium channels are effector mechanism in the implementation of the protective effects of entretenimiento.

Ключевые слова:

entretenimiento, exenatide, vildagliptin, doksorubitsinola cardiomyopathy, isolated heart of rats, ischemia

Вклад авторов

Alla P. Tarasova, Belgorod State National Research University

Postgraduate Student, Department of Pharmacologyand Clinical Pharmacology, Medical Institute.

Lyudmila M. Danilenko, Belgorod State National Research University

Candidate of Pharmaceutical Sciences, Associate Professor, Department of Pharmacologyand and Clinical Pharmacology, Medical Institute.

Lev N. Sernov, Belgorod State National Research University

Honored Scientist of the Russian Federation, Holder of Habilitation Degree in Medicine, Professor, General Director of "Farmkonsalting".

Загрузки

Опубликован

30.12.2017

Как цитировать

Tarasova AP, Danilenko LM, Sernov LN (2017) Effect of pharmacological preconditioning with incretinomimetics exenatide and vildagliptin on the survival of ischemic tissues. Research Results in Pharmacology 3(4): 132–150

Выпуск

Раздел

Экспериментальная фармакология

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