Endothelium and cardioprotective effects of hmg-co-a-reductase in combination with L-arginine in endothelial dysfunction modeling
DOI:
https://doi.org/10.18413/2313-8971-2016-2-1-4-8Abstract
Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of modeling of sepsis-induced disease through the introduction of strain 603 Staphylococcus aureus shows endotelio- and cardioprotective effects, manifesting itself in preventing the proliferation of endothelial dysfunction coefficient (CED), adrenoreactivity, maintenance of myocardial reserve and the normalization of biochemical markers values (Total NO, eNOS expression, C-reactive protein, IL-6, TNF). In this case, the combined therapy was so effective that the values obtained thereunder did not differ from those obtained from control animals.
Keywords:
endothelial dysfunction, HMG-Co-A reductase inhibitor simvastatin, atorvastatin, rosuvastatin, endotoxinDownloads
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Copyright (c) 2016 Research Results in Pharmacology
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