Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction

Authors

  • Ekaterina A. Shakhno Belarusian State University
  • Tatyana Alexandrovna Savitskaya Belarusian State University
  • Tatyana Grigoryevna Pokrovskaya Belgorod State National Research University ORCID logo https://orcid.org/0000-0001-6802-5368
  • Vladimir I. Yakushev Belgorod National Research University
  • Mikhail Vladimirovich Pokrovskii Belgorod National Research University
  • Dmitry D. Grinshpan Belarusian State University

Abstract

For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate the processes of sorption-desorption of L-arginine in a model environment. In animal experiments it was shown that granulirovannye the form of a combined preparation in dosages of 30 mg/kg, 70 mg/kg and 200 mg/kg exhibits a pronounced anti-hypertensive, endothelioprotecive and cardioprotective activity in a dosage of 200 mg/kg.

Keywords:

L-arginine, L-NAME, water-soluble cellulose derivative, activated carbon, immobilized complex, endothelial dysfunction

Author Contribution

Ekaterina A. Shakhno, Belarusian State University

Graduate student of the Department of Physical Chemistry, Faculty of Chemistry of Belarusian State University, Minsk, Belarus

Tatyana Alexandrovna Savitskaya, Belarusian State University

PhD in Chemistry, Professor of Physical Chemistry Department of Belarusian State University, Minsk, Belarus

Tatyana Grigoryevna Pokrovskaya, Belgorod State National Research University

Doctor of Medical Sciences, Professor; Department of pharmacology of Belgorod State National Research University, Belgorod, Russia 

Vladimir I. Yakushev, Belgorod National Research University

Teaching assistant of pharmacological department of Belgorod State National Research University, Belgorod, Russia

Mikhail Vladimirovich Pokrovskii, Belgorod National Research University

PhD, MD, Prof.; Head of the Department of Pharmacology of Belgorod State National Research University, Belgorod, Russia

Dmitry D. Grinshpan, Belarusian State University

Doctor of Chemistry, Professor of Research Institute for Physical Chemical Problems of the Belarusian State University, Minsk, Belarus  

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Published

31-03-2016

How to Cite

Shakhno EA, Savitskaya TA, Pokrovskaya TG, Yakushev VI, Pokrovskii MV, Grinshpan DD (2016) Use of L-arginine immobilised on activated carbon for pharmacological correction of endothelial disfunction. Research Results in Pharmacology 2(1): 30–35

Issue

Vol. 2 No. 1 (2016)

Section

Review article

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