Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium

Авторы

  • Lyudmila M. Danilenko Belgorod National Research University
  • Galina N. Klochkova Belgorod Regional Hospital St. Joasaph
  • Irina V. Kizilova Central District Hospital in Stroitel
  • Mikhail V. Pokrovskii Belgorod National Research University ORCID logo https://orcid.org/0000-0002-1493-3376
  • M.V. Korokin Belgorod National Research University

Аннотация

Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. Key issue is the possibility of drug effects on the mitochondria of cardiomyocytes that controls the aerobic metabolism and maintenance of ATP admission into cardiomyocytes. Moreover mitochondria are the target of ischemia / reperfusion injury and involved in the cardioprotective mechanism ischemia and pharmacologic pre- and postconditioning. Effect of nitric oxide during ischemic reperfusion directed to mitochondria, is considered as the ultimate goal of cardioprotection. Preconditioning effects is begun from sarcolemmal membrane and then is directed to the cytoplasm through a plurality of stages of enzymes, including nitric oxide synthase (NOS), soluble guanylatecyclase (sGC) and protein kinase G (PKG). Thus, the signal is transmitted to the mitochondria, where it occurs cardioprotection. It is proved that the mitochondria provides protection of the heart against ischemia-reperfusion injury by opening the mitochondrial ATP-sensitive K + channels and by converting the capacity of mitochondria. Metabolic modulation concept can be used in the development of strategies cardioprotection for treatment in ischemic / reperfusion myocardial injury.

Ключевые слова:

meldonium, pharmacological preconditioning, ischemic / reperfusion injury, heart

Вклад авторов

Lyudmila M. Danilenko, Belgorod National Research University

PhD in Pharmaceutical Sciences, Associate Professor of the Department of Pharmacology of Medical Institute of NRU BelSU, Belgorod, Russia

Galina N. Klochkova, Belgorod Regional Hospital St. Joasaph

PhD, head of the clinical diagnostic laboratory, OGBUZ "Belgorod Regional Hospital St. Joasaph"
Belgorod, Russia

Irina V. Kizilova, Central District Hospital in Stroitel

Head doctor of Central District Hospital in Stroitel, Belgorod region, Stroitel, Yakovlevsky district,
Belgorod region, Russia

Mikhail V. Pokrovskii, Belgorod National Research University

Doctor of Medicine, Professor of the Department of Pharmacology of pharmacology of Medical  Institute of NRU BelSU, Belgorod, Russia
Scopus

M.V. Korokin, Belgorod National Research University

Doctor of Medicine, Professor of the Department of Pharmacology of pharmacology of Medical Institute of NRU BelSU, Belgorod, Russia 

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Опубликован

29.09.2016

Как цитировать

Danilenko LM, Klochkova GN, Kizilova IV, Pokrovskii MV, Korokin M (2016) Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium. Research Results in Pharmacology: 95–100

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Обзорная статья