Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research)

Авторы

  • Vladimir N. Fedorov Yaroslavl State Medical University
  • Nikolay A. Smirnov Yaroslavl State Medical University
  • Vladimir P. Vdovichenko Grodno State Medical University
  • Tatiana B. Fedorova Yaroslavl State Medical University
  • Edgar E. Kerbenev Yaroslavl State Medical University
  • Alexey K. Petrovsky Yaroslavl State Medical University

DOI:

https://doi.org/10.3897/rrpharmacology.6.56453

Аннотация

Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver. It quite often (up to 20%) causes drug-induced hepatitis. As experimental means of protecting the liver, the following peptides are suggested: chorionic gonadotropin, a recombinant drug of luteinizing hormone – luveris, and oligopeptide drugs: semax and selank.

Materials and Methods: The research was conducted on 104 outbred white male rats weighing 170-220 g. Each group included at least 10 animals. Drug-induced hepatitis was simulated through the combined 21-day administration of isoniazid, rifamycin, and ethanol. Chorionic gonadotropin, luveris, semax and selank, as well as a comparison drug mexidol, were administered once a day during the experiment. Healthy control animals and rats with drug-induced hep­atitis were used as comparison groups. For evaluation of the efficiency of administered drugs, the obtained biochemical and histomorphological research data was used.

Results and Discussion: During the experiment, chorionic gonadotropin (ChG), semax and selank showed a greater therapeutic activity than mexidol and luveris. Only in the case of administering ChG, selank and semax, there was parallelism between the restoration of biochemical parameters of blood and histomorphological parameters of the liver. Administering both selank and ChG was also characterized by more active regenerative processes.

Conclusion: Administering ChG, selank and semax to patients with tuberculosis would significantly reduce the num­ber and severity of hepatotoxic reactions.

Ключевые слова:

tuberculosis, hepatoprotection, hepatoprotector, drug-induced liver lesions, chorionic gonadotropin, luteinizing hormone of hypophysis, semax, selank

Вклад авторов

Vladimir N. Fedorov, Yaroslavl State Medical University

Doctor Habil. of Medical Sciences, Professor, Department of Pharmacology.

Nikolay A. Smirnov, Yaroslavl State Medical University

Candidate of Medical Sciences, Associate Professor, Department of Pharmacology.

Vladimir P. Vdovichenko, Grodno State Medical University

Candidate of Medical Sciences, Associate Professor, Department of Pharmacology.

Tatiana B. Fedorova, Yaroslavl State Medical University

Assistant Professor, Department of Pharmacology.

Edgar E. Kerbenev, Yaroslavl State Medical University

Post-graduate student, Department of Pharmacology.

Alexey K. Petrovsky, Yaroslavl State Medical University

Post-graduate student, Department of Pharmacology.

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Опубликован

25.09.2020

Как цитировать

Fedorov VN, Smirnov NA, Vdovichenko VP, Fedorova TB, Kerbenev EE, Petrovsky AK (2020) Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research). Research Results in Pharmacology 6(3): 33–39. https://doi.org/10.3897/rrpharmacology.6.56453

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