Immune-metabolic genesis of pathological processes

Авторы

DOI:

https://doi.org/10.3897/rrpharmacology.5.38386

Аннотация

This article deals with metabolic-immune processes at rest and under stress conditions, which, in turn, results in the development of immune-dependent and immune-associated disorders. The article analyzes study results and conclusions of various literature sources and experimental data in healthy individuals and patients suffering from non-specific inflammatory lung diseases; purulent-inflammatory diseases and their combinations, primary and secondary progressive multiple sclerosis in the acute stage and remission. Research studies investigated the impact of the type, stage, combination of diseases on the parameters of the immunologic and metabolic statuses, as well as their correlations. The authors also analyzed metabolic effects of immunomodulators. Based on the analysis of the literature and own clinical and experimental data, the authors identified the ability of metabolic factors to regulate immunological processes. A correlative analysis of examination results of the patients with various diseases helped detect the unity of the immune-metabolic mechanisms of pathology. The data on the therapeutic effect of various modulators through differentiated biochemical chains and vice versa – the metabolic effect through immunological mechanisms –were analyzed in the study. Thus, one can testify that there is the phenomenon of a mediated effect of some immunocorrectors on the reactivity through metabolic chains. The fact that a number of modulators and metabolics can simultaneously affect the biochemical and immunological parameters of patients proved the above phenomenon. There was revealed a significant correlation interaction of the immune-metabolic parameters with various types of purulent-inflammatory diseases, which proves the formation of a single mechanism of pathology.

Ключевые слова:

immunomodulators, immunotropic effect, immuno-metabolic parameters, metabolics

Вклад авторов

Andrei M. Zemskov, Voronezh N.N. Burdenko State Medical University

Professor, Doctor of Medical Sciences, Head of the Department of Microbiology.

Tatyana A. Berezhnova, Voronezh N.N. Burdenko State Medical University

Professor, Doctor of Medical Sciences, Head of the Department of Pharmacology.

Veronika A. Zemskova, Voronezh N.N. Burdenko State Medical University

Candidate of Medical Sciences, Assistant Professor of the Department of Pathophysiology.

Kseniya S. Dyadina, Voronezh N.N. Burdenko State Medical University

Assistant of the Department of Pharmacology.

Yana V. Kulintsova, Voronezh N.N. Burdenko State Medical University

Assistant of the Department of Pharmacology.

Anton V. Larin, Voronezh N.N. Burdenko State Medical University

Post-graduate student of the Department of Microbiology.

Загрузки

Опубликован

12.12.2019

Как цитировать

Zemskov AM, Berezhnova TA, Zemskova VA, Dyadina KS, Kulintsova YV, Larin AV (2019) Immune-metabolic genesis of pathological processes. Research Results in Pharmacology 5(4): 19–31. https://doi.org/10.3897/rrpharmacology.5.38386

Выпуск

Раздел

Обзорная статья

Наиболее читаемые статьи этого автора (авторов)