Synthesis and ophthalmic hypotensive effect of new potential benzimidazole-based Rho-kinase-2 inhibitors

Авторы

DOI:

https://doi.org/10.18413/rrpharmacology.12.1121

Аннотация

Разработка новых соединений - потенциальных ингибиторов Rho-киназы-2, обладающих офтальмогипотензивной активностью. С учетом химических структур известных ингибиторов Rho-киназы-2 синтезированы 18 производных бензимидазола, которые были изучены на наличие офтальмогипотензивной активности у животных с нормальным уровнем внутриглазного давления. Проведен анализ зависимости фармакологического эффекта от химической структуры веществ. Для наиболее активных соединений оценено влияние на активность Rho-киназы-2 методом иммуноферментного анализа (ИФА).

Графическая аннотация

Ключевые слова:

glaucoma, benzimidazole, azepan, biphenyl, intraocular pressure, Rho-kinase (ROCK)

Библиографические ссылки

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Вклад авторов

Olga N. Zhukovskaya, Southern Federal University, Rostov-on-Don, Russia

PhD in Chemical Sciences, Senior researcher at the Laboratory of Organic Synthesis, Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia; e-mail: ol@yandex.ru; ORCID ID: http://orcid.org/0000-0003-2485-2139. The author proposed the design of the structures, synthesized the compounds, studied their structure, and wrote the chemical part of text.

Alena S. Taran, Volgograd State Medical University, Volgograd, Russia

PhD of Medical Sciences, Associate Professor, Associate Professor of the Department of Pharmacology and Bioinformatics, Volgograd State Medical University of the Ministry of Health of Russia, Volgograd, Russia; e-mail: alena-beretta-taran@mail.ru; ОRCID ID: https://orcid.org/0000-0001-8477-254X. The author designed the experimental study, participated in the experimental design, and wrote the pharmacologic part of the manuscript.

Lyudmila V. Naumenko, Volgograd State Medical University, Volgograd, Russia

Doctor Habil. of Medical Sciences, Associate Professor, Professor of the Department Pharmacology and Bioinformatics, Volgograd State Medical University of the Ministry of Health of Russia, Volgograd, Russia; e-mail: milanaumenko@mail.ru; ORCID ID: https://orcid.org/0000-0002-2119-4233. The author developed the design of the experimental study.

Alina M. Chebanko, Volgograd State Medical University, Volgograd, Russia

Assistant of the Department of Pharmacology and Bioinformatics, Volgograd State Medical University of the Ministry of Health of Russia, Volgograd, Russia; e-mail: chebanko@yandex.ru; ORCID ID: https://orcid.org/0009-0004-3140-5040. The author took part in conducting experimental work and analyzing the material.

Umida M. Ibragimovа, Volgograd State Medical University, Volgograd, Russia

Assistant of the Department of Pharmacology and Bioinformatics, Volgograd State Medical University of the Ministry of Health of Russia, Volgograd, Russia; e-mail: iumida@list.ru; ORCID ID: https://orcid.org/0000-0001-9141-4417. The author took part in conducting experimental work and analyzing the material.

Anatoly S. Morkovnik, Southern Federal University, Rostov-on-Don, Russia

Doctor Habil. of Chemical Sciences, Head of the Laboratory of Organic Synthesis, Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, Russia; e-mail: asmork@mail.ru; ORCID ID: https://orcid.org/0000-0002-9182-6101. The author was engaged in editing the chemical part of the manuscript.

Alexander A. Spasov, Volgograd State Medical University, Volgograd, Russia

Doctor Habil. of Medical Sciences, Professor, Member of the Russian Academy of Sciences, Head of the Department of Pharmacology and Bioinformatics, Volgograd State Medical University, Volgograd, Russia; e-mail: aspasov@mail.ru; ORCID ID: http://orcid.org/0000-0002-7185-4826. The author proposed the concept and design of the manuscript and approved of the final version of the manuscript.

 

Загрузки

Опубликован

26.06.2026

Как цитировать

Zhukovskaya ON, Taran AS, Naumenko LV, Chebanko AM, Ibragimovа UM, Morkovnik AS, Spasov AA (2026) Synthesis and ophthalmic hypotensive effect of new potential benzimidazole-based Rho-kinase-2 inhibitors. Research Results in Pharmacology 12(2): 131–146. https://doi.org/10.18413/rrpharmacology.12.1121

Выпуск

Том 12 № 2 (2026)

Раздел

Экспериментальная фармакология

Лицензия

Copyright (c) 2026 Zhukovskaya ON, Taran AS, Naumenko LV, Chebanko AM, Ibragimova UM, Morkovnik AS, Spasov AA

Лицензия Creative Commons

Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.

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