The effectiveness of Soderm® – forte gel and a new injectable dosage form of Rexod® in the complex treatment of experimental periodontitis in rats

Авторы

DOI:

https://doi.org/10.3897/rrpharmacology.8.79641

Аннотация

Introduction: Insufficient effectiveness of traditional drug therapy in a treatment of patients with chronic generalized periodontitis, as well as high social significance of this problem, determines the need to search for new drugs and their compositions aimed at solving it.

Aim of the study: To increase the efficacy of complex treatment of periodontitis with the administration of Soder­m®-Forte gel and a new injectable form of Rexod®.

Materials and methods: Experiments were performed in 50 male Wistar rats. Experimental periodontitis (EP) was simulated by ligation of the necks of lower incisors. We studied the animals with intact periodontium, untreated EP, and when traditional drug therapy (TDT), as well as the combinations of TDT with Soderm®-Forte gel and additionally with the new injectable dosage form (NIF) of Rexod® were administered. The general condition, behavior, nutrition and body weight of the animals were evaluated. The Schiller-Pisarev test and the Muhlemann-Cowell bleeding index were used, and the amount of crevicular fluid (CF) was measured. The contamination of the marginal gum with microorganisms was determined.

Results and discussion: The TDT in EP has a moderate therapeutic effect, which does not lead to a sufficiently high pharmacotherapeutic effect, whereas the combinations of TDT with Soderm®-Forte and, to a greater extent, TDT with Soderm®-Forte and NIF of Rexod® have high therapeutic efficacy, which is statistically confirmed by a sharp decrease in the amount of CF, the Schiller-Pisarev test and the Muhlemann-Cowell bleeding index, as well as absolute suppres­sion of pathogenic microorganisms.

Conclusion: The combinations of TDT with Soderm®-Forte gel and NIF of Rexod® in EP in rats can significant­ly increase the effectiveness of the treatment. The data obtained indicate the expediency of the administration of Soderm®-Forte gel, as well as its combination with NIF of Rexod® in dental practice in the complex therapy of patients with periodontitis.

Ключевые слова:

crevicular fluid, new injectable dosage form (NIF) of Rexod®, antimicrobial effect, Soderm®-Forte, experimental periodontitis

Вклад авторов

Pavel A. Galenko-Yaroshevsky, Kuban State Medical University; Research Institute of Pharmacology of Living Systems of Belgorod National Research University

Corresponding member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Head of the Department of Pharmacology

Tseluiko Kristina V., Rostov State Medical University

Postgraduate student of the Department of Pediatric Dentistry.

Valeriy K. Leontev, A.I. Yevdokimov Moscow State University of Medicine and Dentistry; Research Institute of Pharmacology of Living Systems of Belgorod National Research University

Member of the Russian Academy of Sciences, Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor, Vice-President of the Dental Association of Russia, Honored Scientist of the Russian Federation, laureate of the State Prize of the Russian Federation in Science and Technology.

Mark A. Zadorozhniy, Rostov State Medical University

postgraduate student of the Department of Dentistry No.1.

Viktor L. Popkov, Kuban State Medical University

Holder of an Advanced Doctorate (Doctor of Science) in Medical Sciences, Professor of the Department
of Orthopedic Dentistry.

Anait V. Zelenskaya, Kuban State Medical University

PhD in Medical Sciences, Associate Professor of the Department of Pharmacology.

Sergey A. Babichev, Kuban State Medical University

PhD in Medical Sciences, Associate Professor, Head of the Microbiology Department.

Andrey V. Zadorozhniy, Rostov State Medical University

PhD in Medical Sciences, Associate Professor, Head of the Department of Dentistry No.4.

Sonya V. Meladze, Kuban State Medical University

4th year undergraduate student of the Faculty of Dentistry.

Загрузки

Опубликован

31.03.2022

Как цитировать

Galenko-Yaroshevsky PA, Kristina V. T, Leontev VK, Zadorozhniy MA, Popkov VL, Zelenskaya AV, Babichev SA, Zadorozhniy AV, Meladze SV (2022) The effectiveness of Soderm® – forte gel and a new injectable dosage form of Rexod® in the complex treatment of experimental periodontitis in rats. Research Results in Pharmacology 8(1): 51–58. https://doi.org/10.3897/rrpharmacology.8.79641

Выпуск

Том 8 № 1 (2022)

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